Anesthesia for Chronic Pain?
Ketamine is an anesthesia used since the 1960s and has since been proven to work for Chronic Pain and Mental Illness. My pain levels have been through the roof and walking the last 15 days has been difficult. I made the decision to try something radically different. I had my first Ketamine treatment was yesterday.
I read about the LSD effect of Ketamine, this helped me prepare. First, it’s been ages since I’ve done LSD (Acid) and one experience was not pleasant at all. If you’ve not taken LSD you may keep a couple of things in mind.
I wasn’t afraid but started to get nervous as we arrived, I started preparing for this out of body experience. I ask the doctor to include anxiety medicine, the last thing I wanted was a panic attack.
You lay on a table in the patient room, bring your own pillow if you like. That was the worst part of the treatment, those little pillows doubled over. You are in full control of your limbs but maybe be a slower response, the medicine starts to work immediately and you may feel nausea.
Many people go to sleep or half-sleep at this point. I wanted to feel the entire “trip”, the anesthesiologist said if you’re not tripping it’s not working. One of the most common experiences was feeling outside of my body. The people’s voice around me sounded amplified yet I couldn’t make out what they were saying.
I couldn’t get my earbuds to work, crap! I wanted to listen to 70’s Rock & Roll. Instead, I positioned my self sideways and looked outside at the streets. If I let myself there could have been a few anxious moments, I focused on breathing.
I was in a semi-numb state but could handle phone without dropping. Your mind is twisted and turning during the 1.5-hour treatment.
I’m ready to see how this treatment helps.
P.S. It’s hard to know how much the Ketamine treatment worked by itself since the doctor doubled my pain med and wrote a script for topical pain relief. I’ll keep you posted after my next treatment.
Medical information provided by Wikipedia.
Ketamine is a medication mainly used for starting and maintaining anesthesia. It induces a trance-like state while providing pain relief, sedation, and memory loss. Other uses include for chronic pain, sedation in intensive care, and depression. Heart function, breathing, and airway reflexes generally remain functional. Effects typically begin within five minutes when given by injection and last up to about 25 minutes.
Common side effects include agitation, confusion, or hallucinations as the medication wears off. Elevated blood pressure and muscle tremors are relatively common.Spasms of the larynx may rarely occur. Ketamine is an NMDA receptor antagonist, but it may also have other actions.
Ketamine was discovered in 1962, first tested in humans in 1964, and was approved for use in the United States in 1970. It was extensively used for surgical anesthesia in the Vietnam War due to its safety. It is on the World Health Organization’s List of Essential Medicines, the most effective and safe medicines needed in a health system. It is available as a generic medication. The wholesale cost in the developing world is between US$0.84 and US$3.22 per vial. Ketamine is also used as a recreational drug for its hallucinogeniceffects.
See also: Esketamine § Depression
Ketamine has been found to be a rapid-acting antidepressant in depression. It also may be effective in decreasing suicidal ideation, although based on lower quality evidence. The antidepressant effects of ketamine were first shown in small studies in 2000 and 2006. They have since been demonstrated and characterized in subsequent studies. A single low, sub-anesthetic dose of ketamine given via intravenous infusion may produce antidepressant effects within four hours in people with depression. These antidepressant effects may persist for up to several weeks following a single infusion. This is in contrast to conventional antidepressants like selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants (TCAs), which generally require at least several weeks for their benefits to occur and become maximal.Moreover, based on the available preliminary evidence, the magnitude of the antidepressant effects of ketamine appears to be more than double that of conventional antidepressants.On the basis of these findings, a 2017 review described ketamine as the single most important advance in the treatment of depression in over 50 years. It has sparked interest in NMDA receptor antagonists for depression, and has shifted the direction of antidepressant research and development.
Ketamine has not been approved for use as an antidepressant, but its active enantiomer, esketamine, has been. Esketamine was developed as a nasal spray for treatment-resistant depression and is approved for use in the United States. While there is evidence to support the effectiveness of ketamine in treating depression, there is a lack of consensus on optimal dosing and the effects and safety of long-term therapy. Ketamine can produce euphoria and dissociative hallucinogen effects at higher doses, and thus has an abuse potential. Moreover, ketamine has been associated with cognitive deficits, urotoxicity, hepatotoxicity, and other complications in some individuals with long-term use. These undesirable effects may serve to limit the use of ketamine for depression. Dozens of “ketamine clinics” have opened across the United States, where intravenous ketamine is used off-label to treat people with depression.