Stress has been linked to cardiovascular disease, depression, and even the common cold.

Stress is all around us. And while some stressors certainly can feel overwhelming, it’s important to remember that not all stress we face is bad.

The National Institutes of Health says stress is “how the body and brain respond to an external cause that may be a one-time or short-term occurrence or happen repeatedly over a long time.” 

Our body’s response to stressors can sometimes be helpful — giving us a burst of energy to get away from danger or perform well under pressure, explains Michelle Dossett, MD, PhD, MPH, an internist and an integrative medicine specialist at the University of California in Davis.

Anxiety about a doctor’s visit or a performance review at work, for example, or even something scary, like a car heading right at you, are all examples of short-term stressors. 

Long-term stressors have a different effect. “Stress that lasts years or a long time is usually the worst kind of stress,” says Bert Uchino, PhD, a professor of psychology at the University of Utah in Salt Lake City who studies stress in aging populations.

If you’re in a job you hate or you’re a caregiver for a family member with Alzheimer’s disease, for instance, says Dr. Uchino, you may suffer from high levels of chronic (or long-term) stress. That’s where your body “never receives a clear signal to return to normal.”

It’s this type of chronic stress that causes changes in the body that can do damage and contribute to disease in some cases, says Uchino. Blood tests can reveal inflammation, changes in blood pressure, and elevated levels of the stress hormone cortisol, which can all be signs of chronic stress.

9 Illnesses That Stress May Cause or Make Worse

Chronic stress certainly doesn’t help or promote healing in any disease or health problem. Here are some common illnesses that can be caused and made worse by stress.

1. Depression and Other Mental Health Conditions

The exact reason why some people experience depression and anxiety as clinical mood disorders and others do not is still unknown, according to the Centers for Disease Control and Prevention (CDC). Many factors are potentially in play, including genetic, environmental, and psychological conditions, as well as major stressful or traumatic experiences.

Research shows, however, that chronic stress left unmanaged is linked to serious mental disorders like anxiety and depression. Persistent or prolonged stress leads the body to produce certain hormones and chemicals that perpetuate an ongoing state of stress that can have adverse effects on key organs.
Around 20 to 25 percent of persons who experience major stressful events will go on to develop depression, according to a commentary and review of research published in JAMA.

2. Insomnia

An informal APA survey from 2013 on stress and sleep found links in both directions. Forty-three percent of the nearly 2,000 adults surveyed reported that stress had caused them to lie awake at night at least one time in the past month. When they didn’t sleep well, 21 percent reported feeling more stressed. Among adults with higher self-reported stress levels (8 or higher on a 10-point scale), 45 percent said they felt more stressed when they didn’t get enough sleep. Finally, adults with lower self-reported stress levels claimed they slept more hours per night on average than adults with higher self-reported stress levels, to the tune of almost an hour less sleep (6.2 versus 7.1 hours a night).

3. Cardiovascular Disease

Chronic stress has long been connected to worsened heart health outcomes. While there’s limited conclusive evidence to say that stress alone can trigger heart disease, there are quite a few ways stress contributes to it, according to a JAMA review. Part of the stress response is a faster heart rate and blood vessel constriction (or vasodilation for some skeletal muscles to help the body move in a fight or flee response), thanks to the stress hormones adrenaline, noradrenaline, and cortisol, according to research. If the body remains in this state for a long time, as in chronic stress, the heart and cardiovascular system may be damaged, according to other research.

Another means by which stress can contribute to heart disease: You might cope with your stress by eating or drinking too much, which in turn can contribute to cardiovascular disease, also according to APA.“Negative emotions and stress can contribute to a heart attack,” Dr. Dossett says.  One meta-analysis, for example, found a 50 percent increased risk of cardiovascular disease associated with high levels of work stress.

4. Common Cold

Stress can also weaken your immune function, which can make you more susceptible to infectious diseases like colds, Uchino explains. Researchers conducted an experiment in which they exposed a group of 420 volunteers to the common cold virus and then quarantined them to see if they got sick. The data revealed that participants who suffered from greater overall stress at the start of the study (measured via surveys on stressful life events, perceived stress, and mood) were more likely to become infected with a virus after exposure.

5. HIV and AIDS

Stress does not cause HIV (the virus that causes AIDS, which is sexually transmitted or passed through blood, which can happen when needles are shared). But there is some evidence that stress can worsen severity of the disease. A study of 177 HIV-positive patients found that the stress hormone cortisol (associated with chronic stress) was linked to a higher HIV viral load over four years and accelerated disease progression in people living with HIV. For the study, cortisol levels were measured via urine samples every six months.

Another review, published in 2016, concluded that while the link between stress and clinical outcomes is unclear, higher stress was linked to lower disease-fighting white blood cell counts, higher viral load, and disease worsening. Studies also linked stress with worse treatment adherence, per the review.

6. Gastrointestinal Disease

“Stress can affect gastrointestinal motility,” says Dossett, which is how food moves through your digestive system, increasing your chances of irritable bowel syndrome, inflammatory bowel conditions, gastroesophageal reflux, constipation, diarrhea, and discomfort. “All those things can be impacted by stress,” she says. Research supports this as well.

7. Chronic Pain

Some chronic pain conditions like migraine and lower back pain can be caused, triggered, or worsened when body muscles tense up. A lot of chronic low back pain is related to stress, says Dossett. “Very often it’s muscle tension and tightness that is pulling or creating strain, and then contributing to this sensation of pain.”

A study published in 2021 confirmed a strong relationship between the degree of stress and chronic lower back pain. The researchers concluded that clinicians who treated patients with chronic low back pain should also evaluate a patient’s stress levels.

“Pain is inherently stressful. When the pain does not appear to be remitting or getting better, the concern regarding the pain can turn into fear, anxiety, and hopelessness,” says Joel Frank, PsyD, a psychologist in private practice in Sherman Oaks, California. 

A review published in 2017 examined the overlap between chronic stress and chronic pain, finding that both conditions triggered similar responses in the brain, particularly in the hippocampus and amygdala. The researchers also noted, however, that because of the wide variety of ways humans experience chronic pain and stress, these two conditions do not always overlap.

8. Cancer

What causes cancer is a particularly challenging question to answer, says Uchino. Because most patients are diagnosed only after years of cancer cell growth, it’s difficult if not impossible to pinpoint a specific cause. And it’s likely that several factors (someone’s genes, plus an environmental trigger like smoking, air pollution, or stress, for example) contribute.

But there is some evidence in human studies that stress plays a role in the onset of cancer, Uchino says. (It’s also worth noting that some studies have found no link.)

One possible reason why stress might contribute to some cancers: Stress can activate your brain and body’s inflammatory response, as well as stimulating your adrenal glands to release stress hormones called glucocorticoids, among many other downstream effects. Some research suggests that too much of this type of inflammation from chronic stress is the connection with cancer (as well as some autoimmune diseases — see below), Dossett explains.

9. Autoimmune Conditions

“Many inflammatory conditions are exacerbated by stress, and that includes autoimmune conditions like multiple sclerosis, rheumatoid arthritis, lupus, psoriatic arthritis, and psoriasis,” says Dossett. A Swedish population-wide study published in the June 2018 issue of JAMA found that patients with a stress disorder were more likely to develop an autoimmune disorder (9 per 1,000 patients per year compared with 6 per 1,000 among those without stress disorders). Another extensive review on the role of stress in autoimmunity emphasized that this is a relationship that medicine often overlooks.

Summary

The good news is there are many effective ways to manage stress, says Dossett, including yoga and mindfulness. These types of interventions don’t undo or change whatever situation is causing stress (financial woes, a family argument, or a busy schedule), but they can retrain the body’s central nervous system’s response and help dial that response down if it’s been triggered.

But some conditions, such as cardiovascular disease, develop years before they are diagnosed, so more research into interventions is desperately needed, says Uchino.

All things considered, if you want help with your chronic stress or other psychological issues, it’s best to ask your doctor or a trained mental health provider to evaluate and support you based on your needs.

Melinda

Reference:

https://www.everydayhealth.com/emotional-health/stress/illnesses-caused-stress/?utm_source=bphope&utm_medium=referral&utm_campaign=ehnetwork-bphope&utm_content=bphope-newsletter-hhh-2025-02-20